353 VALPROIC ACID (VPA): STEADY-STATE PHARMACOKINETICS IN PEDIATRIC PATIENTS WITH SEIZURES
نویسندگان
چکیده
منابع مشابه
Therapeutic Drug Monitoring of Valproic Acid in Patients with Monotherapy at Steady State
Objective(s) The role of therapeutic drug monitoring (TDM) in patient care has grown rapidly since its introduction three decades ago. The aim of present study was to evaluate the possible relationship between serum levels and the clinical response of valproic acid (VPA). Materials and Methods In the present study we evaluated a homogeneous group of adult patients receiving VPA monotherapy. ...
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Free and total valproic acid (VPA) pharmacokinetic evaluation was carried out at steady state in six young epileptics who were also receiving other anticonvulsants. Subjects received their usual morning dose of VPA after an overnight fast. Blood samples for free and total VPA were taken prior to the dose and frequently thereafter for 12 hours. The calculated pharmacokinetic parameters for total...
متن کاملtherapeutic drug monitoring of valproic acid in patients with monotherapy at steady state
objective(s) the role of therapeutic drug monitoring (tdm) in patient care has grown rapidly since its introduction three decades ago. the aim of present study was to evaluate the possible relationship between serum levels and the clinical response of valproic acid (vpa). materials and methods in the present study we evaluated a homogeneous group of adult patients receiving vpa monotherapy. a t...
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Steady-state serum concentrations of carbamazepine (CBZ) and valproic acid (VPA) were investigated in normal weight (body mass index; BMI 20 to 25), lean (smaller than 20 BMI) and moderately obese subjects (greater than 25 BMI) who received either 400 mg/day of CBZ or 800 mg/day of VPA. The CBZ serum concentration in lean subjects was significantly higher than that in normal weight subjects. Ho...
متن کاملPopulation pharmacokinetics of intravenous valproic acid in Korean patients.
OBJECTIVE To determine population-based pharmacokinetic parameters for intravenous valproic acid, and the factors influencing these parameters, in Korean adults. METHODS Valproic acid concentrations were obtained using a peak and trough sampling scheme for 102 Korean epileptic patients who were not taking concurrent antiepileptic medication. Three hundred and fifty-four serum concentrations w...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1981
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198104001-00364